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Preclinical Services

Screening of compounds in various models is a prerequisite to find out their molecular mechanism. DR Biosciences offers a wide range of services using in-vitro models.

Cytotoxicity Studies                               Hepatoprotective Activity            Cardioprotective Activity                     Nephroprotective Activity

Neuroprotective Activity                      Anticancer Activity                        Anti-Inflammatory Activity                Anti-diabetic Activity

Anti-hyperlipidemic Activity               Apoptosis Assay

Anti-bacterial Assay

Proteomics

A cell or an organism regulates the activity and level of its proteins in response to internal and external changes. Proteomics is the systematic and high-throughput approach to this differential protein expression. A typical proteomic analysis data yields information on the expressed and repressed proteins across multiple conditions. Post-translational modifications, protein-protein interactions, protein function and localization studies are carried out  as part of proteomic studies. DR Biosciences offers a comprehensive workflow of the given services to a researcher to perform proteome analysis.

​SDS-PAGE

2-Dimensional gel electrophoresis

Western Blotting

Immunoprecipitation   

Chip-Assay

Post Translational Modifications

Cell Biology

DR Biosciences carries out a range of studies to determine the toxicity of a compound on cells. We believe a successful evaluation of a compound forms a stepping stone for further studies. The service offering provided to achieve the goal using different cell line:

​MTT Assay                                          Gene Over-expression                Gene silencing (siRNA, shRNA)       Wound Healing Assy                       Primary cell preparation                  Stable cell line preparation       Agarose Gel Electrophoresis            Signaling Pathway Studies

Genomics

The concept of Genomics is not only restricted by sequencing of the genome but also includes epistasis, heterosis, pleitrophy, interaction between various loci and alleles with in a genome. As defined by WHO, Genomics is the study of genes and their functions and related techniques, DR Biosciences actively pursues various technologies associated with Genomics like

​RNA isolation & Quantification          DNA isolation & Quantification         Plasmid isolation

Agarose Gel Electrophoresis                Primer design                                        cDNA synthesis                                        

Gene Mutations                                     Southern blotting                                  Cloning                                  

DNA damage by Comet assay             Genotyping                                             Gene expression analysis by RT-PCR

Enzyme assays

Enzyme assays play an integral part of analysis to visualize enzyme activities as enzymes play a critical role in most of cellular processes. To be able to provide the researcher with the ability to delve into the various enzymatic processes, DR Biosciences offers a range of assays mentioned below

Antioxidant Status (Catalase, GPx, SOD, GR, GSH)    NADPH oxidase activity

Xanthine Oxidase activity                                              Aconitase Assay

PKC activity                                                                       Nitric oxide synthase Activity

Mitochondrial Complex Activities                                Carbohydrate and Lipid Metabolism related Enzymes

Biochemical Studies

Hematology                                             Plasma Biochemical profile

TBARS & Protein carbonyls                  Pro-inflammatory Cytokines

Hormones

Histopathology

H & E Staining                                         Imaging & Quantification

Oil Red O Staining                                  Tissue Sectioning & Imaging 

Biomarker Analysis

We use latest technologies for the detection of biomarkers invarious body tissues and fluids.

ELISA                                                          Culture Method                                 PCR & RT-PCR based Method              

Antibody Mediated Technology             

Enzyme activity based Assay

Analytical Services

Pharmacokinetic Studies                                     Method development and validation of various formulations  

Analysis of various phytoconstituents              Quantification of various drug concentrations in Plasma, tissues and other body fluids

Other Services

Customized Phyto-extracts preparation                                            Analysis of Food material composition       

Isolation of various cellular organelles and their membranes      Poject works for Master, M.Phil, PhD and Manuscript Writing

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